accuse 和charge都有“指责，控告”之意，有时可通用，但结构不一样。accuse不一定针对重大过失或罪行，其结构为accuse sb of sth。而charge一般用于重大过失或罪行，其结构为charge sb with sth，此结构还有“使某人负有……责任”之意。例如：

例1：My father accused me of my being too careless. (父亲责备我太粗心。)

例2：He accused me of neglecting my duty. (他指控我玩忽职守。)

例3：He charged me with neglecting my duty. (同上)

例4：Jimmy was charged with murder. (吉米被控谋杀。)

例5：He was charged with an important task. (他担负有一项重要任务。)